San Francisco-based healthcare AI startup Arintra has closed a $25 million Series B led by Define Ventures, taking total funding to $51 million. Existing investors Peak XV Partners, Yale New Haven Health's Center for Health Care Innovation, Endeavor Health Ventures, Y Combinator, Counterpart Ventures, Ten13 and Spider Capital all joined the round, which Arintra says will fund an aggressive push across more enterprise health systems and new corners of the revenue cycle.
Autonomous coding as the enterprise standard
Arintra's platform pairs large language models with clinical knowledge graphs to read patient charts in context, apply specialty-specific rules and generate fully justified codes inside the EHR. The company positions itself as the first agentic-AI "revenue assurance" platform, unifying autonomous coding, clinical documentation intelligence (CDI), denials appeals, DRG validation and payer insights on one stack — replacing a patchwork of point tools that traditionally leaves compliant revenue on the table.
Deployed across UC Davis, Rochester Regional and Endeavor
The company already processes more than $5 billion in annual claim value for enterprise health systems representing over $50 billion in combined net patient revenue, including UC Davis Health, Rochester Regional Health, Mercyhealth, Meritus Health, Reid Health and Mercy Medical Center. Arintra reports customers see a 5.1% increase in compliant revenue capture, 32% lower cost to collect and a 43% drop in coding-related denials, while an EHR-embedded audit trail lets human coders validate results roughly 50% faster than manual review, according to UC Davis Health.
Coder shortages meet a $5 trillion payments problem
The Series B lands as U.S. health systems fight rising financial pressure and a persistent shortage of certified coders, even as they try to collect from a $5 trillion payments system riddled with denials and inaccuracy. "No solution to date has been comprehensive and strategic enough to provide health systems with the bottom-line impact they need — until Arintra," said Define Ventures partner Chirag Shah. Arintra co-founder and CEO Nitesh Shroff added that "revenue assurance isn't optional anymore. It's how health systems build a financial foundation that matches the quality of care they deliver."
What the money buys
Fresh capital will fund deeper specialty coverage — Arintra adds roughly two new specialties per quarter to its current 23 — plus expansion into further revenue-cycle stages and new enterprise deployments. The platform is already listed in the Epic Toolbox and on the athenahealth Marketplace, is HITRUST e1 certified and earned an A+ performance rating in a 2026 KLAS Emerging Company Spotlight. The round adds to a growing crop of agentic health-AI raises tracked on TheRoboticsMedia, from MiiHealth's DAINA seed to Onos Health's Series A and Hike Medical's automation raise.
Reporting based on coverage from PR Newswire, Fierce Healthcare and HIT Consultant.