Houston-based digital therapeutics startup developing a wirelessly powered brain implant for treatment-resistant depression.
Motif Neurotech is a Houston-based digital therapeutics company developing the Motif XCS System, a small wirelessly powered implant that delivers gentle electrical stimulation to a brain region clinically shown to reduce depressive symptoms in adults who have not responded to multiple medications.
The company's flagship DOT implant is the size of a blueberry, delivered in a 20-minute outpatient procedure without exposing or contacting the brain. In April 2026, Motif received FDA Investigational Device Exemption approval for the RESONATE Early Feasibility Study — the first U.S. clinical trial of a wireless brain implant for treatment-resistant depression.